Global NeuroDiscovery Challenge

MIND THE DATA

Search for Gender Based Differences In Alzheimer’s Disease

 

Abstract

  • The goal of the 2013 Geoffrey Beene Global NeuroDiscovery Challenge is to identify male/female differences in the pathogenesis and presentation of Alzheimer’s disease (AD) in the pre-symptomatic, early symptomatic and late stages of AD. The objective of this Challenge is to generate novel hypotheses addressing the causes and consequences of such differences.

  • The Solvers are also expected to provide a rationale supported by available data and a detailed research plan describing how to test the hypothesis. Of particular interest are hypotheses that can be validated in a secondary phase by mining existing AD databases for analysis of variables associated with gender differences in AD.

  • This Challenge requires only a written proposal.

Summary

  • New insights, paradigms and tools are urgently needed to gain a better understanding of the processes associated with the pathogenesis and presentation of Alzheimer’s disease (AD) in both women and men. This new knowledge will not only help reveal the existence of biologic male/female differences at different stages of the disease but will also contribute to a mechanistic understanding of the neurodegenerative cascade in AD.

  • To address this need, the Geoffrey Beene Foundation Alzheimer’s Initiative (GBFAI), through the launch of its 2013 Geoffrey Beene Global NeuroDiscovery Challenge, seeks to identify male/female differences in the pathogenesis and presentation of Alzheimer’s disease (AD) in the pre-symptomatic, early symptomatic and late dementia stages because answers may come from looking across the spectrum of the disease.


  • The objective of this Challenge is to generate novel hypotheses addressing the causes and consequences of such differences. All novel hypotheses related to the topic are encouraged.

  • This is a Theoretical Challenge that requires only a written proposal to be submitted. The Challenge award will be contingent upon theoretical evaluation of the proposal by the Seeker.

  • To receive an award, the Solvers will not have to transfer their exclusive intellectual property (IP) rights to the Seeker. Instead, they will grant to the Seeker non-exclusive license to practice their solutions.

  • GBFAI and other Challenge Sponsors are extremely interested in further development of one or more of the Winning Solutions after the completion of this Challenge. While interest and ability to implement the Solutions are not required to win an award, Solvers should indicate their interest (or lack thereof) in participating in the follow-up implementation of their proposal.

Click here to read the 2013 Geoffrey Beene Global NeuroDiscovery
Challenge Press Release