Enrico Glaab-profileEnrico Glaab, PhD

 

 

 

 

Enrico Glaab, PhD

I am a research associate at the Luxembourg Centre for Systems Biomedicine, belonging to the University of Luxembourg.

Originally from Frankfurt in Germany, I received my BSc and MSc degree in Computational Molecular Biology at Saarland University, Germany, and then started my doctoral studies as Marie Curie Research Fellow at Nottingham University, United Kingdom. After completing the PhD, I spent a short time as a postdoctoral researcher at the European Molecular Biology Laboratory in Heidelberg, Germany, and then moved together with our Bioinformatics research group, headed by Dr. Reinhard Schneider, to the newly established Luxembourg Centre for Systems Biomedicine (LCSB).

My research at the LCSB is centered around the development and application of statistical learning, pathway- and network-analysis techniques for large-scale biological data, in particular biomedical datasets for neurodegenerative diseases.

Previously, I have been working on the integrative analysis of brain gene expression deregulations during adult aging and in Parkinson’s disease. When I heard about the challenge and noticed articles in the literature suggesting a potential age-dependence of gender differences in Alzheimer’s disease (AD), I investigated this in more detail using a statistical analysis of data from a large-scale case-control study on AD and aging-related data from unaffected individuals. This analysis pointed to a specific candidate gene, and further network and literature mining analyses revealed both known and new potential regulatory links to proteins and pathways known to be involved in AD and other neurodegenerative disorders. These results were the basis for my submission.

During the last years of her life, my grandmother suffered from dementia. Her sister is now developing similar symptoms, but in both cases there was no diagnosis of AD. None of my relatives or friends has ever been diagnosed with the disease.